Health and Biology
The activity "Magnetic nanoparticles for biotechnology" started at SPINTEC in 2008. It benefits from the know-how of the laboratory in magnetic materials, spin-electronics and nanofabrication. Our efforts are mainly focused towards the fabrication of engineered magnetic nanoparticles prepared by top-down approaches and specially designed for specific applications. Magnetic nanoparticles are more and more used in biotechnology because they allow exerting torques or forces on biological species thanks to magnetic field or gradient of magnetic field. The major fields of applications are sorting of biological species, targeted drug delivery, hyperthermia, contrast agents for magnetic resonance imaging (MRI) or magnetic particle imaging (MPI), tissue engineering, triggering of cancer cells destruction, etc.
Questions to be addressed
New types of nanostructured and functionalized magnetic particles are investigated and developed, perfectly controlled in composition, shape and size. The outcome can be quite important in the biomedical field, with perspectives of applications in various areas such as biotechnology, biological sensors, nanomechanics, micro/nano-robotics, fundamental studies on forces in biological species.
Synthetic antiferromagnetic micro or nanoparticles exhibiting “superparamagnetic-like” properties are elaborated by a top-down approach, and released in solution by lift-off. They can have a much higher susceptibility and magnetization moment than conventional spherical magnetite based particles.
- Project NANO-SHARK : Micro / nano magnetic functionalized tweezers dispersed in solution for biological and medical applications, supported by ANR (National Research Agency) with the ref ANR-11-NANO–001, and a thesis.
- Project supported by Région Rhône-Alpes CIBLE 2012 : Magnetic nanoparticles for biotechnology, in particular for MRI (Magnetic Resonance Imaging)
- Thesis : Magnetic flagellar artificial micro or nano-swimmers functionalized for biotechnology
- Thesis : Treatment of cancer tumours, based on the magneto-mechanical vibration of biofunctionalized nanoparticles, yielding the apoptosis - destruction by their "suicide" - of targeted cancer cells.
- Laboratoire INAC/SPrAM/CREAB : Functionalization, biotechnological applications
- Laboratoire INAC/SCIB : Biological applications on cancer cells targeting and destruction
- Laboratoire INAC/SCIB : Biological MRI (Magnetic Resonance Imaging)
- Laboratoire LTM (CNRS) : Microfluidics
- Laboratoire LTM (CNRS) : Nanofabrication using diblock copolymers technics
- ANR (National Research Agency) supporting the Project P2N NANO-SHARK, ref ANR-11-NANO–001.
- Discussions fructueuses :
- Institut Louis Néel (CNRS)
- Prof. François ALOUGES, Applied Mathematics : Low Reynolds Swimming, École Polytechnique, CMAP
- PTA Plateforme Technologique Amont (Clean room platform)
- Participation à l’Alliance BIO dans LA NEF
Hélène JOISTEN - Responsible for the thematic BIO
Bernard DIENY – Scientific Direction
Hélène JOISTEN – Characterization, modeling
Philippe SABON – Technological research
PhD students (2011-2014) :
PhD students (2012-2015) :