HEALTH AND BIOLOGY

Overview

The activity “Health and Biology” benefits from the know-how of the laboratory in magnetic materials, spin-electronics and nanofabrication. Our efforts are mainly focused towards the fabrication of engineered magnetic micro- nano- particles or devices, prepared by top-down approaches, specially designed for biomedical applications, such as cancer cells destruction triggering, tissue engineering.

Research directions

Magnetic particles for cancer treatment

particles

A biomedical application using anisotropic magnetic nanoparticles, aiming at the targeted destruction of cancer cells, by triggering their apoptosis / necrosis, thanks to the vibration of the particles attached to the membranes, in low magnetic fields of low frequency (~20 Hz).

Magnetic metamaterials for biological applications

metamaterials

Metamaterials, whose functionality is controlled by external magnetic fields, aiming at biological applications. The materials consist of micromotors or microtweezers, comprising ferromagnetic particle pairs embedded in a polymer matrix, and magneto-elastic membranes.

The team

Permanent staff

ID-MOREL
Robert MOREL
robert.morel@cea.fr
JOISTEN

Hélène JOISTEN
helene.joisten@cea.fr

Bernard DIENY 041
Bernard DIENY
bernard.dieny@cea.fr

Post-docs

  • Svetlana PONOMAREVA (2017-2018)

PhD

  • Cécile NAUD (2015-2018)

Former members

Post-docs

  • Alain TRUONG (2015-2017)

PhD

Projects

  • ABIOMATER, H2020 FET Open, 2015-2018
  • APOTRIG, Agir PEPS Univ. Grenoble Alpes, 2015-2016
  • Nano-Shark, ANR P2N, 2011-2016
  • Cible2012, Rhône-Alpes land, 2012-2015

Partners

  • Biomedial research center
    • CLINATEC Lab/INSERM/CHU/UGA (targeted cancer cells and tumor destruction, in vitro & in vivo): François Berger (Neuro-cancerologist, tumor nano-medicine), Matthieu Dreyfus.
  • Biology Laboratories
    • INAC/SYMMES/LAN (toxicity, cancer cells, in vitro biological applications) Marie Carrière
    • INAC/SYMMES/CREAB (surface biochemical functionalization) Yanxia Hou-Broutin
    • TheREx/TIMC-IMAG, CNRS UMR 5525 (cancer cells) Bertrand Toussaint
  • Microelectronics technology
    • LTM (Nanofabrication using block copolymer template) Ahmad Bsiesy, Thierry Baron
    • LTM (Microfluidics) David Peyrade

Recent news

  • Nanoviber – An ERA-NET project at SPINTEC (November 26th, 2016)
    Overview NANOVIBER (EURONANOMED-II ERA-NET project) was accepted at the Fall 2016. Context: Despite the progress of chemo-radiotherapy, molecular and cellular therapies as well as neurosurgery, glioblastoma remains a deadliness disease. Beside drugs, radiotherapy and surgery, “physical” therapies are ...
  • 7TH NAMIECEB WORKSHOP AWARD (July 02nd, 2015)
    Selma LEULMI a gagné un prix du meilleur Poster, décerné par la Fondation Nanosciences lors de la Journée « 7th Workshop ’Nano & Micro-Environments for Cell Biology’ » du 30/01/2014. Selma LEULMI received the Poster Award ...
  • DES VIBRATIONS MORTELLES POUR LES CELLULES CANCÉREUSES (July 02nd, 2015)
    En oncologie, les nanoparticules magnétiques sont utilisées pour brûler les cellules cancéreuses. Un nouvel usage, basé sur leur vibration au contact de ces cellules, est à l’étude par les chercheurs du CEA-Inac. Pour un traitement ...
  • DES NANOPARTICULES À L’ASSAUT ! (July 02nd, 2015)
    En vibrant à leur contact sous l’effet d’un champ magnétique externe, des nanoparticules peuvent infliger à des cellules tumorales un stress mécanique fatal. Des physiciens de l’Inac ont élaboré et testé deux familles de nanoparticules. ...
  • DESTRUCTION OF TARGETED CANCER CELLS (July 02nd, 2015)
    Application of bio-functionalized magnetic micro-particles elaborated by the top-down approach Selma Leulmi is a PhD student at SPINTEC with background both in nanotechnology and biology who conducts the study on triggering cancer cell apoptosis. This particular ...

Publications

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