HEALTH AND BIOLOGY

Overview

The activity “Magnetic biotechnologies” benefits from the know-how of the laboratory in magnetic materials, nanomagnetism, spin-electronics and nanofabrication. Our efforts are mainly focused towards the fabrication of engineered magnetic micro- nano-particles or devices, designed to apply forces on biological species. Their biomedical applications such as cancer cells destruction or stimulation of insulin production are investigated in collaboration with biology labs.

Research directions

Magnetic microdisks for cancer treatment

Magnetic microdisks for the destruction of targeted cancer cells induced by their low frequency mechanical vibrations (20 Hz) under alternating external magnetic field. (C.Naud et al, NANOSCALE ADVANCES, 2, 3632 (2020))

Arrays of flexible magnetic cantilevers

Arrays of flexible magnetic cantilevers used as micropumps, microswimmers or for magnetic field mapping thanks to their optical properties (A.Truong et al, Scientific reports 6 (2016) 31634)

The team

Former members

Post-docs

  • Svetlana PONOMAREVA (2017-2019)
  • Alain TRUONG (2015-2017)

PhD

  • Cécile NAUD (2015-2018)

Projects

  • NANOVIBER ANR/EURONANOMED 2017-2020
  • ABIOMATER, H2020 FET Open, 2015-2018
  • APOTRIG, Agir PEPS Univ. Grenoble Alpes, 2015-2016
  • Nano-Shark, ANR P2N, 2011-2016
  • Cible2012, Rhône-Alpes land, 2012-2015

 

Partners

  • Biomedial research center
    • BrainTech Lab   INSERM/UGA (targeted cancer cells and tumor destruction, in vitro & in vivo): François Berger (Neuro-oncologist, tumor nano-medicine), Matthieu Dreyfus.
  • Biology Laboratories
    • IRIG/SYMMES/LAN (toxicity, cancer cells, in vitro biological applications) Marie Carrière
    • IRIG/SYMMES/CREAB (surface biochemical functionalization) Yanxia Hou-Broutin
  • Microelectronics technology
    • LTM (Force microscopy on cells) Alice Nicolas

Recent news

  • DES VIBRATIONS MORTELLES POUR LES CELLULES CANCÉREUSES (July 02nd, 2015)
    En oncologie, les nanoparticules magnétiques sont utilisées pour brûler les cellules cancéreuses. Un nouvel usage, basé sur leur vibration au contact de ces cellules, est à l’étude par les chercheurs du CEA-Inac. Pour un traitement ...
  • DES NANOPARTICULES À L’ASSAUT ! (July 02nd, 2015)
    En vibrant à leur contact sous l’effet d’un champ magnétique externe, des nanoparticules peuvent infliger à des cellules tumorales un stress mécanique fatal. Des physiciens de l’Inac ont élaboré et testé deux familles de nanoparticules. ...
  • DESTRUCTION OF TARGETED CANCER CELLS (July 02nd, 2015)
    Application of bio-functionalized magnetic micro-particles elaborated by the top-down approach Selma Leulmi is a PhD student at SPINTEC with background both in nanotechnology and biology who conducts the study on triggering cancer cell apoptosis. This particular ...
  • MICROSWIMMERS (July 02nd, 2015)
    Magnetic flagellar artificial micro or nano-swimmers functionalized for biotechnology Description The study, based on a top-down approach, aims at developing a new type of functionalized artificial micro/ nanoswimmers with magnetic flagella, for biotechnological applications. Partners SPINTEC : Nanomagnetism integrated ...
  • NANO-SHARK (July 02nd, 2015)
    Micro / nano magnetic functionalized tweezers dispersed in solution for biological and medical applications Description A new type of functionalized magnetic nanoparticles is developed, consisting in micro- nanomagnetic tweezers, attached to the substrate or released in solution, ...

Publications

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